DEVELOPING NOVEL BACTERIOPHAGES FOR THERAPY

As the antibiotic resistance crisis grows to epidemic proportions, our lab is trying to fundamentally rethink our approach to treating bacterial infection. We are using bacteriophages ("phages") that co-evolve with bacteria to "outsmart" bacterial adaptation and acquired antibiotic resistance. Phages are viruses that specifically invade and destroy bacteria without harming eukaryotic cells. By modifying phage-host receptor interactions or by neutralizing other mechanisms that cause phresistance. We are developing a broad technology platform for designing customized phages to kill pathogenic microbes using synthetic biology tools, with a focus on developing phages against urinary tract infection.