As the antibiotic resistance crisis grows to epidemic proportions, our lab is trying to fundamentally rethink our approach to treating bacterial infection. We are using bacteriophages ("phages") that co-evolve with bacteria to "outsmart" bacterial adaptation and acquired antibiotic resistance. Phages are viruses that specifically invade and destroy bacteria without harming eukaryotic cells. By modifying phage-host receptor interactions or by neutralizing other mechanisms that cause phresistance. We are developing a broad technology platform for designing customized phages to kill pathogenic microbes using synthetic biology tools, with a focus on developing phages against urinary tract infection.

Department of Biochemistry

441B HF DeLuca Biochemistry Laboratories Building

433 Babcock DriveUniversity of Wisconsin-Madison

Madison, WI – 53706

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