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Mapping the Molecular Rules of Life at Scale

Mapping the Molecular Rules of Life at Scale

What we do

We decode how sequence encodes function and use those rules to engineer biology.

Measure at scale

Deep mutational scanning Barcoded genomes & pooled selections

Learn principles

Machine learning models

Causal inference & prediction

Design of function

Programmable proteins & phages

Tuned transporters & sensors

Platforms: DMS • Barcoded libraries • ML   |   Outcomes: diagnostics, therapeutics, biomanufacturing

Our Partners

Featured Breakthroughs

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Hidden Allosteric Networks Revealed

We mapped thousands of mutations across allosteric proteins, uncovering regulatory principles invisible to traditional structural approaches.

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Phage Genome Essentiality at Scale

PhageMaP enabled the first systematic deletion landscape of viral genomes, revealing cooperative gene networks.

Single-Cell Chromatin Rewiring by Oncofusions

PROD-ATAC uncovered how dozens of oncogenic fusions reshape chromatin accessibility in human cells.

Meet our Team

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Vatsan Raman, Ph.D

Associate Professor

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Jackie Chen

Graduate Student 

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Rebecca Back

Graduate Student 

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Phil Huss

Graduate Student 

Department of Biochemistry

371C HF DeLuca Biochemistry Laboratories Building

433 Babcock Drive, University of Wisconsin-Madison

Madison, WI – 53706

© 2026 by Raman Laboratory

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